ID:
TE0016A
Duration (hours):
68
CFU:
8
SSD:
BIOLOGIA MOLECOLARE
Located in:
CHIETI
Url:
SUSTAINABLE TECHNOLOGIES AND ENVIRONMENTAL TOXICOLOGY/CORSO GENERICO Year: 3
Year:
2026
Course Catalogue:
Overview
Date/time interval
Primo Semestre (01/03/2025 - 31/01/2026)
Syllabus
Course Objectives
The course aims to provide students with an in-depth understanding of the fundamental principles of genetic information, molecular processes, and genetic manipulation technologies. Students will acquire both theoretical and practical skills related to DNA, RNA, proteins, genetically modified organisms, and biotechnological applications, developing critical analysis, experimental design, and risk assessment abilities related to biosafety and environmental impacts.
Intended Learning Outcomes
By the end of the course, the student will be able to:
Knowledge and Understanding
Describe the structure and function of nucleic acids, genome organization, and fundamental processes of replication, transcription, RNA maturation, translation, and gene regulation, including epigenetic mechanisms and non-coding RNAs.
Understand environmentally induced genetic alterations, DNA repair systems, and gene and chromosomal mutations.
Know the main molecular biology technologies, such as PCR, cloning, sequencing, and genotoxicity testing.
Understand the principles of genetic modification in cells, animals, and plants, including overexpression, gene silencing, and gene editing, as well as their applications in research, industry, and agriculture.
Applying Knowledge and Understanding
Design and perform experiments using molecular biology techniques and genetic manipulation methods.
Analyze and interpret experimental data related to gene expression and genetic modifications.
Apply concepts of biosafety and risk assessment in the use of genetically modified organisms.
Making Judgments
Critically evaluate experimental methodologies and scientific data.
Formulate hypotheses and experimental strategies based on molecular and genetic knowledge.
Identify the limitations and potential of genetic technologies and biotechnological applications.
Communication Skills
Communicate scientific concepts, methods, and results clearly, both in written and oral form.
Prepare laboratory reports, scientific presentations, or posters using appropriate technical terminology.
Learning Skills
Independently keep up to date with new discoveries and techniques in molecular biology and applied genetics.
Integrate theoretical and practical knowledge to develop independent experimental strategies.
Intended Learning Outcomes
By the end of the course, the student will be able to:
Knowledge and Understanding
Describe the structure and function of nucleic acids, genome organization, and fundamental processes of replication, transcription, RNA maturation, translation, and gene regulation, including epigenetic mechanisms and non-coding RNAs.
Understand environmentally induced genetic alterations, DNA repair systems, and gene and chromosomal mutations.
Know the main molecular biology technologies, such as PCR, cloning, sequencing, and genotoxicity testing.
Understand the principles of genetic modification in cells, animals, and plants, including overexpression, gene silencing, and gene editing, as well as their applications in research, industry, and agriculture.
Applying Knowledge and Understanding
Design and perform experiments using molecular biology techniques and genetic manipulation methods.
Analyze and interpret experimental data related to gene expression and genetic modifications.
Apply concepts of biosafety and risk assessment in the use of genetically modified organisms.
Making Judgments
Critically evaluate experimental methodologies and scientific data.
Formulate hypotheses and experimental strategies based on molecular and genetic knowledge.
Identify the limitations and potential of genetic technologies and biotechnological applications.
Communication Skills
Communicate scientific concepts, methods, and results clearly, both in written and oral form.
Prepare laboratory reports, scientific presentations, or posters using appropriate technical terminology.
Learning Skills
Independently keep up to date with new discoveries and techniques in molecular biology and applied genetics.
Integrate theoretical and practical knowledge to develop independent experimental strategies.
Course Prerequisites
To take the Molecular Biotechnology and GMOs exam you must have passed the Biochemistry exam
Teaching Methods
Teaching activities will be divided into lectures and laboratory exercises.
The lectures last 2 hours each and include a 10-15 minute break at the end of
the first hour. Students are warmly invited to ask questions both during and at the end of the lectures.
The final part of the course will be devoted to laboratory exercises on
molecular biology methods covered in the lectures.
The exercises will be explained in detail and carried out by the students
divided into small groups. All activities will be supervised step-by-step by the
professor assisted by experts in the subject.
The lectures last 2 hours each and include a 10-15 minute break at the end of
the first hour. Students are warmly invited to ask questions both during and at the end of the lectures.
The final part of the course will be devoted to laboratory exercises on
molecular biology methods covered in the lectures.
The exercises will be explained in detail and carried out by the students
divided into small groups. All activities will be supervised step-by-step by the
professor assisted by experts in the subject.
Assessment Methods
Learning assessment will take place at the end of the course, during the scheduled exam sessions, through an oral examination in the form of an interview, covering multiple topics from the program.
The outcome of the exam is expressed on a scale of thirty points. Assessment takes into account the level of knowledge demonstrated, the appropriateness of the scientific language used, as well as the clarity, coherence, and logical rigor of the exposition.
Assessment Criteria
The exam is graded on a thirty-point scale according to the following levels:
18–22/30: sufficient basic knowledge, though with gaps;
23–25/30: fair knowledge accompanied by clear exposition;
26–28/30: good command of the subject and ability to present topics using appropriate language;
28–30/30: very thorough knowledge, excellent exposition skills, and critical reasoning.
Honors (cum laude) are awarded to students who demonstrate particularly advanced knowledge, outstanding presentation skills, and strong critical thinking abilities.
Students with disabilities, Specific Learning Disorders (SLD), or other special educational needs may receive individualized accommodations during examinations, in accordance with current regulations and with the provisions of the University’s Service Charter (https://www.unich.it/sites/default/files/2024-02/carta_dei_servizi_0.pdf), following an agreement with the course instructor. To request compensatory or dispensatory measures, students must contact the CON_TE_STO Service and follow the procedure outlined in the Service Charter. Students are encouraged to contact the instructor during the course, or in any case well in advance of the examination date, in order to be informed about the exam format and the accommodations that may be granted. For guidance and referral to the various services offered by the University, students may contact the Department’s Reference Instructor: Prof. Letizia Giampietro (letizia.giampietro@unich.it).
The outcome of the exam is expressed on a scale of thirty points. Assessment takes into account the level of knowledge demonstrated, the appropriateness of the scientific language used, as well as the clarity, coherence, and logical rigor of the exposition.
Assessment Criteria
The exam is graded on a thirty-point scale according to the following levels:
18–22/30: sufficient basic knowledge, though with gaps;
23–25/30: fair knowledge accompanied by clear exposition;
26–28/30: good command of the subject and ability to present topics using appropriate language;
28–30/30: very thorough knowledge, excellent exposition skills, and critical reasoning.
Honors (cum laude) are awarded to students who demonstrate particularly advanced knowledge, outstanding presentation skills, and strong critical thinking abilities.
Students with disabilities, Specific Learning Disorders (SLD), or other special educational needs may receive individualized accommodations during examinations, in accordance with current regulations and with the provisions of the University’s Service Charter (https://www.unich.it/sites/default/files/2024-02/carta_dei_servizi_0.pdf), following an agreement with the course instructor. To request compensatory or dispensatory measures, students must contact the CON_TE_STO Service and follow the procedure outlined in the Service Charter. Students are encouraged to contact the instructor during the course, or in any case well in advance of the examination date, in order to be informed about the exam format and the accommodations that may be granted. For guidance and referral to the various services offered by the University, students may contact the Department’s Reference Instructor: Prof. Letizia Giampietro (letizia.giampietro@unich.it).
Texts
BIOLOGIA MOLECOLARE; Casa Editrice Ambrosiana
Francesco Amaldi Piero Benedetti Graziano Pesole Paolo Plevani
FONDAMENTI DI BIOLOGIA MOLECOLARE
Lizabeth A. Allison
BIOTECNOLOGIE MOLECOLARI
Terry A. Brown
Contents
Structure of nucleic acids, organisation and maintenance of genomes, transcription and translation, regulation of gene expression. Main genome editing techniques. Use of GMOs in the pharmaceutical industry for the production of recombinant proteins, in agricultural production and breeding to improve production and resistance to pathogens. Genetic and epigenetic damage induced by mutagenic agents and techniques for their monitoring. Use of microorganisms for waste treatment and/or remediation of contaminated environments.
Course Language
Italian
More information
Course attendance is strongly recommended
Student reception times are to be agreed with the lecturer by e-mail (michele.sallese@unich.it).
Student reception times are to be agreed with the lecturer by e-mail (michele.sallese@unich.it).
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Degrees
SUSTAINABLE TECHNOLOGIES AND ENVIRONMENTAL TOXICOLOGY
Bachelor’s Degree
3 years
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