Factors associated with first- versus second-generation long-acting antipsychotics prescribed under ordinary clinical practice in Italy
Articolo
Data di Pubblicazione:
2018
Abstract:
Background: For many years, long-acting intramuscular (LAI) antipsychotics have been prescribed predominantly to chronic and severe patients, as a last resort when other treatments failed. Recently, a broader and earlier use of LAIs, particularly second-generation LAIs, has been emphasized. To date, few studies attempted to frame how this change in prescribing took place in real-world practice. Therefore, this study aimed to describe the clinical features of patients prescribed with LAIs, and to explore possible prescribing differences between first- and second-generations LAIs under ordinary clinical practice in Italy.
Methods: The STAR Network "Depot" Study is an observational, longitudinal, multicenter study involving 35 centers in Italy. In the cross-sectional phase, patients prescribed with LAIs were consecutively recruited and assessed over a period of 12 months. Descriptive statistics and multivariable logistic regression analyses were employed.
Results: Of the 451 recruited patients, 61% were males. The level of social and working functioning was heterogeneous, as was the severity of disease. Seventy-two per cent of the patients had a diagnosis of the schizophrenia spectrum. Seventy per cent were prescribed with second-generation antipsychotic (SGA) LAIs (mostly paliperidone, aripiprazole and risperidone). Compared to first-generation antipsychotic (FGA) LAIs, patients prescribed with SGA LAIs were more often younger; employed; with a diagnosis of the schizophrenia spectrum or bipolar disorder; with higher levels of affective symptoms; with fewer LAI prescriptions in the past.
Discussion: LAIs' prescribing practices appear to be more flexible as compared to the past, although this change is mostly restricted to SGA LAIs.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Adolescent; Adult; Antipsychotic Agents; Cross-Sectional Studies; Female; Humans; Italy; Longitudinal Studies; Male; Middle Aged; Prescriptions; Schizophrenia
Elenco autori:
Ostuzzi, G.; Mazzi, M. A.; Terlizzi, S.; Bertolini, F.; Aguglia, A.; Bartoli, F.; Bortolaso, P.; Callegari, C.; Caroleo, M.; Carra, G.; Corbo, M.; D'Agostino, A.; Gastaldon, C.; Lucii, C.; Magliocco, F.; Martinotti, G.; Nose, M.; Ostinelli, E. G.; Papola, D.; Piccinelli, M. P.; Piccoli, A.; Purgato, M.; Tabacchi, T.; Turrini, G.; Ruggeri, M.; Barbui, C.; De Fazio, P.; Raffaele, G.; Chirico, M.; Cavallotti, S.; Bolognesi, S.; Debolini, S.; Pierantozzi, E.; Fargnoli, F.; Del Zanna, M.; Giannini, A.; Luccarelli, L.; De Capua, A.; Annese, P. M.; Cerretini, M.; Tozzi, F. -E.; Magnani, N.; Cardamone, G.; Bardicchia, F.; Facchi, E.; Soscia, F.; Zotos, S.; Biancosino, B.; Zonta, F.; Pompei, F.; Zizolfi, D.; Poloni, N.; Ielmini, M.; Caselli, I.; Giana, E.; Buzzi, A.; Diurni, M.; Milano, A.; Sani, E.; Calzolari, R.; Piccinelli, M.; Cazzamalli, S.; Alberini, G.; Piantanida, S.; Costantini, C.; Paronelli, C.; Di Caro, A.; Moretti, V.; Gozzi, M.; D'Ippolito, C.; Barbanti, S. V.; Alessandro, P.; Campese, O.; Fiori, F.; Lorusso, M.; Di Capro, L.; Viceconte, D.; Mancini, V.; Suraniti, F.; Signorelli, M. S.; Rossi, E.; Lupoli, P.; Menchetti, M.; Terzi, L.; Boso, M.; Risaro, P.; De Paoli, G.; Catania, C.; Tarricone, I.; Caretto, V.; Storbini, V.; Emiliani, R.; Balzarro, B.; Nava, R.; Bono, A.; Provenzi, M.; Brambilla, G.; Aspesi, F.; Tremolada, M.; Castagna, G.; Bava, M.; Verrengia, E.; Lucchi, S.; Oriani, M. G.; Barchiesi, M.; Pacetti, M.; Magni, L. R.; Rossi, G.; Beneduce, R.; Tura, G. B.; Laffranchini, L.; Mastromo, D.; Ferrato, F.; Restaino, F.; Monzani, E.; Porcellana, M.; Limosani, I.; Ghio, L.; Ferro, M.; Parise, V. F.; Balletta, G.; Addeo, L.; De Vivo, E.; Benedetto, R. D.; Pinna, F.; Carpiniello, B.; Spano, M.; Giacomin, M.; Pecile, D.; Mattei, C.; Fabrici, E. P.; Panarello, S.; Peresson, G.; Vitucci, C.; Bonavigo, T.; Perini, G.; Boschello, F.; Strizzolo, S.; Gardellin, F.; Di Giannantonio, M.; Moretti, D.; Fizzotti, C.; Cossetta, E.; Gregorio, L. D.; Sozzi, F.; Boncompagni, G.; La Barbera, D.; Colli, G.; Laurenzi, S.; Calandra, C.; Luca, M.
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