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  1. Pubblicazioni

Advancements in the Research of New Modulators of Nitric Oxide Synthases Activity

Articolo
Data di Pubblicazione:
2024
Abstract:
Nitric oxide (NO) has been defined as the "miracle molecule" due to its essential pleiotropic role in living systems. Besides its implications in physiologic functions, it is also involved in the development of several disease states, and understanding this ambivalence is crucial for medicinal chemists to develop therapeutic strategies that regulate NO production without compromising its beneficial functions in cell physiology. Although nitric oxide synthase (NOS), i.e., the enzyme deputed to the NO biosynthesis, is a well-recognized druggable target to regulate NO bioavailability, some issues have emerged during the past decades, limiting the progress of NOS modulators in clinical trials. In the present review, we discuss the most promising advancements in the research of small molecules that are able to regulate NOS activity with improved pharmacodynamic and pharmacokinetic profiles, providing an updated framework of this research field that could be useful for the design and development of new NOS modulators.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
activators; cancer; cardiovascular diseases; drug design; inflammation; inhibitors; natural sources; neurodegenerative diseases; nitric oxide; nitric oxide synthase
Elenco autori:
Maccallini, Cristina; Budriesi, Roberta; De Filippis, Barbara; Amoroso, Rosa
Autori di Ateneo:
AMOROSO Rosa
DE FILIPPIS Barbara
MACCALLINI Cristina
Link alla scheda completa:
https://ricerca.unich.it/handle/11564/837211
Link al Full Text:
https://ricerca.unich.it//retrieve/handle/11564/837211/449222/ijms-25-08486.pdf
Pubblicato in:
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Journal
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URL

https://www.mdpi.com/1422-0067/25/15/8486
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