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Angiogenic Events Positively Modulated by Complex Magnetic Fields in an In Vitro Endothelial Cell Model

Articolo
Data di Pubblicazione:
2025
Abstract:
The vascular system is primarily responsible for orchestrating the underlying healing processes to achieve tissue regeneration, thus the promotion of angiogenic events could be a useful strategy to repair injured tissues. Among several approaches to stimulate tissue regeneration, non-invasive devices are currently widely diffused. Complex Magnetic Fields (CMFs) are innovative pulsed multifrequency electromagnetic fields used for their promising results in clinical applications, such as diabetic foot treatment or edema resorption. Nevertheless, few papers are available demonstrating the biological mechanisms involved. In this paper, in order to understand CMFs’ capability to promote angiogenic events, Regenerative Tissue Program (RTP) was applied to an in vitro Endothelial Cells (ECs) model. ECs were stimulated with (I) 2 RTP consecutive cycles, (II) with an interval of 8 h (T0 + T8), or (III) 24 h (T0 + T24) from one cycle to another. Results demonstrate that (I) extracellular matrix degradation is promoted through matrix metalloproteinases 2 and 9 modulation, leading to an increased cell migratory capability; (II) CMFs support EC growth, activating Integrin β1-Erk-Cdk2 pathway and sustaining G1/S transition; (III) vessel morphogenesis is promoted when CMFs are applied. In conclusion, the promising clinical results are supported by in vitro analyses which evidence that main angiogenic events are stimulated by CMFs.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
angiogenesis; complex magnetic fields; endothelial cells; extracellular matrix remodeling; healing processes; tissue regeneration
Elenco autori:
Ricci, A.; Cataldi, A.; Gallorini, M.; di Giacomo, V.; Rapino, M.; Di Pietro, N.; Mantarro, M.; Piattelli, A.; Zara, S.
Autori di Ateneo:
CATALDI Amelia
DI GIACOMO Viviana
DI PIETRO NATALIA
GALLORINI MARIALUCIA
RICCI ALESSIA
ZARA SUSI
Link alla scheda completa:
https://ricerca.unich.it/handle/11564/855133
Link al Full Text:
https://ricerca.unich.it//retrieve/handle/11564/855133/514762/cells-14-00332.pdf
Pubblicato in:
CELLS
Journal
Progetto:
Innovation, digitalisation and sustainability for the diffused economy in Central Italy - VITALITY
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URL

https://www.mdpi.com/2073-4409/14/5/332
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