Skin is one of the first lines of defense of the immune system. It has protective and defensive functions and can resist bacteria. Open wounds damage skin and soft tissues, and improper treatment will lead to the growth of pathogenic bacteria inside the wounds. These bacteria can invade the blood circulatory system and cause bacterial infections. Directly using antibiotics and other antibacterial drugs may cause bacteria to develop resistance and invade the human immune system. Antimicrobial resistance (AMR) is one of the major global health threats, and the research of new antibacterial materials is a major challenge in the antibacterial field. Generally, the condition of patients infected with MDR bacteria is more complicated, and the treatment is relatively difficult. The most widely used dressing for open wounds is hydrogel. Wound dressings usually require materials with high biological activity, but some synthetic materials will inevitably face the problem of unsatisfactory biocompatibility. The aim will be to assess smart drug release systems based on hydrogel vectors prepared with peptide and peptide-like substances, improving the efficacy and safety of antimicrobial drugs and offering many advantages over conventional delivery systems such as non-invasive controlled-release patterns. These systems can enhance the pharmacokinetics and biodistribution of antimicrobial drugs, increasing their effective bioavailability, reducing their dosage frequency, and improving their antimicrobial efficacy against biofilm-related infections while slowing the development of antimicrobial resistance. The research group consists of researchers with deep experience in the field of microbiology and biochemistry who can follow each step of the research plan until the development of a drug-delivery system based on natural/semi-synthetic biopolymers (possibly anionic) with antimicrobial, immunomodulatory properties based on the active ingredient selected.