Muscarinic Receptors Expression in the Peripheral Blood Cells Differentiate Dementia with Lewy Bodies from Alzheimer's Disease
Academic Article
Publication Date:
2021
abstract:
Central nervous system disruption of cholinergic (ACh) signaling, which plays a major role in cognitive processes, is well documented in dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). The expression of muscarinic ACh receptors type 1 and 4 (CHRM1 and CHRM4) has been reported to be altered in the brain of DLB patients.
Iris type:
1.1 Articolo in rivista
Keywords:
Alzheimer’s disease; cholinergic imbalance; dementia with Lewy bodies; muscarinic receptors; real time-polymerase chain reaction
List of contributors:
Reale, Marcella; Carrarini, Claudia; Russo, Mirella; Dono, Fedele; Ferri, Laura; Pietro, Martina Di; Costantini, Erica; Porreca, Annamaria; Nicola, Marta Di; Onofrj, Marco; Bonanni, Laura
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