Publication Date:
2015
abstract:
The present invention refers to humanized anti-Trop-2 antibodies and their fragments, derivatives and conjugates that are able to recognise and bind with high affinity distinct regions of the Trop-2 molecule. The present invention also teaches the use of such antibodies and of pharmaceutical compositions thereof for diagnosis and therapy of human pathologies, in particular cancer.
Iris type:
6.1 Brevetto
Keywords:
Trop-2, humanized monoclonal antibodies, ADCC, anticancer therapy, preclinical efficacy
List of contributors: