GUARNIERI Simone

Professor Simone Guarnieri is an Associate Professor of Physiology (SSD BIOS-06/A) at the “G. d’Annunzio” University of Chieti-Pescara, within the Department of Neuroscience, Imaging and Clinical Sciences. His scientific activity is centered on muscle and neuronal physiology, with a particular focus on signal transduction mechanisms regulating intracellular calcium homeostasis, mitochondrial bioenergetics, and cellular oxidative status. Throughout his career, he has investigated Ca²⁺ dynamics, membrane electrical activity, and reactive oxygen species (ROS), analyzing how these processes contribute to the functional regulation of skeletal and cardiac muscle cells, neuronal cells, and other cellular models. A significant part of his research has been devoted to the functional role of Growth Associated Protein 43 (GAP-43) in skeletal muscle and myocardium, with particular attention to its involvement in calcium regulation and cellular adaptation mechanisms. Another major research area concerns cellular responses to environmental physical stimuli, including simulated microgravity, low-frequency electromagnetic fields, and hypoxic conditions. In this context, he has participated in and coordinated national research projects, contributing to the understanding of cellular adaptation processes and functional modifications induced by variations in mechanical and gravitational forces. His profile is characterized by strong methodological expertise, including patch-clamp and cellular electrophysiology techniques, confocal and multiphoton microscopy, live-cell imaging, and fluorimetric analysis of second messengers. Alongside his research activity, he is actively involved in teaching within medical and biomedical degree programs, holding academic coordination and organizational responsibilities. Overall, his scientific career is distinguished by an integrated approach combining cellular physiology, biophysics, and advanced imaging technologies, with relevant applications in cardiovascular, neuromuscular, and biomedical research.