Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme.
Articolo
Data di Pubblicazione:
2012
Abstract:
The development of a novel class of pharmacodynamic hybrids that inhibits COX-2 isoform is reported. These molecules display enhanced nitric oxide releasing properties due to the presence of an ionisable moiety. The in vivo analgesic/anti-inflammatory activity was maintained in relation to the parent compounds.
Tipologia CRIS:
1.1 Articolo in rivista
Elenco autori:
Biava, M; Battilocchio, C; Poce, G; Alfonso, S; Consalvi, S; Porretta, Gc; Schenone, S; Calderone, V; Martelli, A; Testai, L; Ghelardini, C; Di Cesare Mannelli, L; Sautebin, L; Rossi, A; Giordani, A; Patrignani, Paola; Anzini, M.
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