Synthesis, physicochemical characterization and analysis of drug delivery systems in nanotechnology and nanomedicine. Students will learn fundamentals for the synthesis, physicochemical characterization and biological tests of drug delivery systems and medical devices. The course aims at proposing a comprehensive view of basal procedures and assays used for the biological evaluation of newly synthetized compounds, nanomaterials and drug delivery.
Course Prerequisites
Pharmaceutical Technology with laboratory Human Anatomy
Teaching Methods
Classes activities. Individual activities. Training activities. 12 hours of lectures.
Assessment Methods
Oral discussion/presentation of topics included in the program. 4 different questions, 2 questions for each modules discussing the thematic issues of the program Minimum score for the approval: 18/30. Oral examination/presentation.
Texts
Caliceti Paolo et al., Principi di tecnologie farmaceutiche, Ambrosiana, Milano, Ultima edizione. AULTON Tecnologie Farmaceutiche, Progettazione e allestimento dei medicinali, Caviglioli G., Coviello T., De Rosa G., Modena T., Ultima edizione. A.T. FLORENCE, D. ATTWOOD Le basi chimico-fisiche della tecnologia farmaceutica. Edises Ultima edizione
Contents
FUNDAMENTALS OF DRUG DELIVERY SYSTEMS: Introduction to drug delivery systems and nanomedicine. DRUG DELIVERY SYSTEMS: Fundamentals: Differences between drug delivery systems and conventional drug dosage form. Mechanisms of diffusion and transport of drugs modulated by drug delivery systems. Biopharmaceutical and technological properties of drug delivery systems. Biomaterials in drug delivery. Passive and active targeting. Lipid and polymeric drug delivery systems. Nanometric implantable devices. -saggio ELISA. -Trafficking intracellulare, vie endocitiche e trasporto tramite vescicolazione: -cenni alle vie endocitiche ed esocitiche, apparato del Golgi. Obiettivi Agenda 2030 per lo sviluppo sostenibile (ATTENZIONE: posizionarsi su questo campo per poter selezionare gli obiettivi dalla lista) Salute e Benessere. Istruzione di Qualità. Uguaglianza di genere. Ridurre le disuguaglianze. Obiettivi per lo sviluppo sostenibile Codice Descrizione 3 Salute e benessere 4 Istruzione di qualità 5 Uguaglianza di genere 10 Ridurre le disuguaglianze Examples of drug delivery systems: Lipid drug delivery systems (Doxil/Caelyx). Polymeric drug delivery systems (Abraxane). Nanochannel biomedical devices (nDS). Cell organization and communication. In vitro cell culture models: primary cell cultures, normal and cancer cell lines. In vitro metabolic activity and cytotoxicity assays. Study of the intracellular trafficking in response to different pharmaceutical systems by means of flow cytometry, fluorescence microscopy, transmission and scanning electron microscopy, atomic force microscopy.
Course Language
Italian
More information
Individual meeting with students in the teaching office to discuss the relative unclear topics
