Multiple brain abscesses of odontogenic origin. May oral microbiota affect their development? a review of the current literature

first_pagesettingsOrder Article Reprints Open AccessReview Multiple Brain Abscesses of Odontogenic Origin. May Oral Microbiota Affect Their Development? A Review of the Current Literature by Nicola Montemurro 1,2ORCID,Paolo Perrini 1,2ORCID,Walter Marani 3,Bipin Chaurasia 4,Massimo Corsalini 5ORCID,Antonio Scarano 6ORCID andBiagio Rapone 7,*ORCID 1 Department of Neurosurgery, Azienda Ospedaliera Universitaria Pisana (AOUP), 56100 Pisa, Italy 2 Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa, 56126 Pisa, Italy 3 Unit of Neurosurgery, Mater Dei Hospital, 70121 Bari, Italy 4 Department of Neurosurgery, Bangladesh State Medical University, Dhaka 1205, Bangladesh 5 Interdisciplinary Department of Medicine, University of Bari, 70121 Bari, Italy 6 Department of Oral Science, Nano and Biotechnology and CeSi-Met University of Chieti-Pescara, 66100 Chieti, Italy 7 Department of Basic Medical Sciences, Neurosciences and Sense Organs, “Aldo Moro” University of Bari, 70121 Bari, Italy * Author to whom correspondence should be addressed. Appl. Sci. 2021, 11(8), 3316; https://doi.org/10.3390/app11083316 Received: 13 March 2021 / Revised: 3 April 2021 / Accepted: 4 April 2021 / Published: 7 April 2021 (This article belongs to the Special Issue Biomaterials, Nanomaterials and Microbiota Biofilm Control in Dentistry) Download Browse Figure Review Reports Versions Notes Abstract In the last few years, the role of oral microbiota in the setting of oral diseases such as caries, periodontal disease, oral cancer and systemic infections, including rheumatoid arthritis, cardiovascular disease and brain abscess (BA), has attracted the attention of physicians and researchers. Approximately 5–7% of all BAs have an odontogenic origin, representing an important pathological systemic condition with a high morbidity and mortality. A systematic search of two databases (Pubmed and Ovid EMBASE) was performed for studies published up to 5 January 2021, reporting multiple BAs attributed to an odontogenic origin. According to PRISMA guidelines, we included a total of 16 papers reporting multiple BAs due to odontogenic infections. The aim of this review is to investigate the treatment modality and the clinical outcome of patients with multiple BAs due to odontogenic infections, as well as to identify the most common pathogens involved in this pathological status and their role, in the oral microbiota, in the onset of oral infections. A multidisciplinary approach is essential in the management of multiple BAs. Further studies are required to understand better the role of microbiota in the development of multiple BAs.