Data di Pubblicazione:
2009
Abstract:
Mutations in the Grb10-interacting GYF protein 2 (GIGYF2) gene, within the PARK11 locus, have been nominated as a cause of Parkinson's disease in Italian and French populations. By sequencing the whole GIGYF2 coding region in forty-six probands (thirty-seven Italians) with familial Parkinson's disease compatible with an autosomal dominant inheritance, we identified no mutations. Our data add to a growing body of evidence suggesting that GIGYF2 mutations are not a frequent cause of PD.
Tipologia CRIS:
1.1 Articolo in rivista
Elenco autori:
DI FONZO, A; Fabrizio, E; Thomas, Astrid Maria; Fincati, E; Marconi, R; Tinazzi, M; Breedveld, Gj; Simons, Ej; Chien, Hf; Ferreira, Jj; Horstink, Mw; Abbruzzese, G; Borroni, B; Cossu, G; DALLA LIBERA, A; Fabbrini, G; Guidi, M; DE MARI, M; Lopiano, L; Martignoni, E; Marini, P; Onofrj, Marco; Padovani, A; Stocchi, F; Toni, V; Sampaio, C; Barbosa, Er; Meco, G; ITALIAN PARKINSON GENETICS, Network; Oostra, Ba; BONIFATI V., GIGYF MUTATIONS ARE; PARKINSONISM RELAT DISORD, NOT A. FREQUENT CAUSE OF FAMILIAL PARKINSON'S D. I. S. E. A. S. E.; Nov,
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