The ultrastructure of coronaropathy studied on human biopsies during BPAC

The ultrastructural study of wronaric biopsies withdrawn beneath the plaque has shown interesting aspects on polymorphism of atherosclerotic lesions which isn't well known in iiterature yet. The endothelium of the so-cailed 'uninjured' coronary shows all the known and 'strange' alterations of single cells:lost of glicocalix, ribosornial activationfibrils production, dense wrpora, fractures of desmosomic junctions and detaching from basai membrane; acti- vated plaielets infilirate these bared parts. In the micro-fractures the oxidate LDL 'et-similia' graze the endothelium during perfusion then they damage it and penetrate in the W&. This is the atherogenesis ddevelopment. In the inflammatary microfocus we have often observed numerous contacts between macrophages and lymphocytes.