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Assessment of the in-vitro toxicity and in-vivo therapeutic capabilities of Juglans regia on human prostate cancer and prostatic hyperplasia in rats

Articolo
Data di Pubblicazione:
2024
Abstract:
Benign prostatic hyperplasia (BPH) and prostatic cancer are aging-associated urological conditions in men. While significant advances have been made in relation to treatment, poor response, treatment resistance and adverse side-effects limit currently available therapies. The possible antiproliferative and/or ameliorative potentials of Juglans regia have been reported, however, there is a dearth of scientific information on its effect on BPH or prostatic cancer. In this study, in-vivo and in-vitro studies were used to assess the possible benefits of fresh walnut fruits extract in BPH or prostate cancer. High-performance liquid chromatography coupled with electro spray ionization and quadrupole-time-of-flight mass spectrometry (HPLC-ESI-Q-TOF) was used to assess the chemical profile of the plant extract. The anti-proliferative activity of Juglans regia extract was tested against normal and cancerous human prostate cell lines by using the iCELLigence real-time and label-free cell analysis system. The ameliorative potential of fresh fruits Juglans regia extract was assessed by administering the extract at 50 and 100 mg/kg body weight to rats with testosterone induced BPH. Analysis of phytochemicals in Juglans regia revealed a high concentration of phenolic acids and flavonoids, Juglans regia also showing time- and dose-dependent antiproliferative activity against prostate cancer cells, and reversed biochemical and histomorphological changes induced by testosterone-induced BPH.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Fresh fruits Juglans regia; Antioxidants; Cell lines; Prostate; Prostate specific antigen; Phytochemicals
Elenco autori:
Stefanucci, Azzurra; Marinaccio, Lorenza; Llorent-Martínez, Eulogio J.; Zengin, Gokhan; Bender, Onur; Dogan, Rumeysa; Atalay, Arzu; Adegbite, Omotayo; Ojo, Foluso O.; Onaolapo, Adejoke Y.; Onaolapo, Olakunle J.; Mollica, Adriano
Autori di Ateneo:
MARINACCIO LORENZA
MOLLICA ADRIANO
STEFANUCCI AZZURRA
Link alla scheda completa:
https://ricerca.unich.it/handle/11564/840591
Link al Full Text:
https://ricerca.unich.it//retrieve/handle/11564/840591/456042/1-s2.0-S2212429223011902-main.pdf
Pubblicato in:
FOOD BIOSCIENCE
Journal
Progetto:
Innovation, digitalisation and sustainability for the diffused economy in Central Italy - VITALITY
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URL

https://www.sciencedirect.com/science/article/pii/S2212429223011902
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