Skip to Main Content (Press Enter)

Logo UNICH
  • ×
  • Home
  • Corsi
  • Insegnamenti
  • Professioni
  • Persone
  • Pubblicazioni
  • Strutture
  • Terza Missione
  • Attività
  • Competenze

UNI-FIND
Logo UNICH

|

UNI-FIND

unich.it
  • ×
  • Home
  • Corsi
  • Insegnamenti
  • Professioni
  • Persone
  • Pubblicazioni
  • Strutture
  • Terza Missione
  • Attività
  • Competenze
  1. Pubblicazioni

Orthostatic hypotension is associated with higher levels of circulating endostatin

Articolo
Data di Pubblicazione:
2024
Abstract:
Aims The pathophysiology of orthostatic hypotension (OH), a common clinical condition, associated with adverse outcomes, is incompletely understood. We examined the relationship between OH and circulating endostatin, an endogenous angiogenesis inhibitor with antitumour effects proposed to be involved in blood pressure (BP) regulation. Methods We compared endostatin levels in 146 patients with OH and 150 controls. A commercial chemiluminescence sandwich im- and results munoassay was used to measure circulating levels of endostatin. Linear and multivariate logistic regressions were conducted to test the association between endostatin and OH. Endostatin levels were significantly higher in OH patients (59 024 ± 2513 pg/mL) vs. controls (44 090 ± 1978pg/mL, P < 0.001). A positive linear correlation existed between endostatin and the magnitude of systolic BP decline upon standing (P < 0.001). Using multivariate analysis, endostatin was associated with OH (adjusted odds ratio per 10% increase of endostatin in the whole study population = 1.264, 95% confidence interval 1.141–1.402), regardless of age, sex, prevalent cancer, and cardiovascular disease, as well as traditional cardiovascular risk factors. Conclusion Circulating endostatin is elevated in patients with OH and may serve as a potential clinical marker of increased cardiovascular risk in patients with OH. Our findings call for external validation. Further research is warranted to clarify the underlying pathophysiological mechanisms.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Blood pressure; Endostatin; Orthostatic hypotension
Elenco autori:
Ricci, Fabrizio; Larsson, Anders; Ruge, Toralph; Galanti, Kristian; Hamrefors, Viktor; Sutton, Richard; Olshansky, Brian; Fedorowski, Artur; Johansson, Madeleine
Autori di Ateneo:
GALANTI KRISTIAN
RICCI FABRIZIO
Link alla scheda completa:
https://ricerca.unich.it/handle/11564/847845
Link al Full Text:
https://ricerca.unich.it//retrieve/handle/11564/847845/471726/Ricci_EHJOpen2024.pdf
Pubblicato in:
EUROPEAN HEART JOURNAL OPEN
Journal
Progetto:
Innovation, digitalisation and sustainability for the diffused economy in Central Italy - VITALITY
  • Utilizzo dei cookie

Realizzato con VIVO | Designed by Cineca | 25.6.1.0