Contrasting effects of NO on food intake and GH secretion stimulated by a GH releasing peptide (GHRP)

Objective. Based on NO involvement in the GH-releasing effect of the GH-releasing peptides (GHRP s) and the reported orexigenic activity of these compounds, we sought to evaluate the effect of the combined administration of a long-acting NO-donor, molsidomine, and/or an inhibitor of NO-synthase, N-nitro-arginine-methyl-ester (NAME). and the GHRP EP92632 on food-intake and GH secretion. Results. EP92632 significantly stimulated food-intake (3A±0.6 vs. 2,6±0.7g, P<0.01), an effect which was further enhanced by molsidomine (6.4±0.6g. P