Relation between Pro-inflammatory Cytokines and Acetylcholine Levels in Relapsing-Remitting Multiple Sclerosis Patients
Articolo
Data di Pubblicazione:
2012
Abstract:
Abstract: Multiple sclerosis (MS) is a chronic inflammatory, demyelinating and
neurodegenerative disorder. Since acetylcholine (ACh) is known to participate in the
inflammatory response, we investigated the possible relationship between
pro-inflammatory cytokines and acetylcholine levels in relapsing-remitting multiple
sclerosis (RR-MS) patients. Levels of ACh and pro-inflammatory cytokines IL1-β and
IL-17 were measured both in cerebrospinal fluid (CSF) and sera of 22 RR-MS patients in
the relapsing phase and in 17 control subjects affected by other non-neurological diseases
(OND). We observed higher levels of pro-inflammatory cytokines such as IL-1β and IL-17
in both CSF and serum of RR-MS patients compared to control subjects. Moreover, ACh
levels were lower in CSF and serum of RR-MS patients compared to levels of control
subjects. Although the relationship between high inflammatory cytokine levels and low
OPEN ACCESS
Int. J. Mol. Sci. 2012, 13 12657
ACh levels need to be further investigated in the future, our data suggest that IL-1β, and
cytokines induced by it, such as IL-17 and ACh, may be involved in the pathogenesis
of MS.
Tipologia CRIS:
1.1 Articolo in rivista
Elenco autori:
Reale, Marcella; Federica de, Angelis; DI NICOLA, Marta; Elisabetta, Capello; DI IOIA, Maria; DE LUCA, Giovanna; Lugaresi, Alessandra; Ada Maria, Tata
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