Investigating the role of MCTR1 in muscle recovery and performance under high intensity hypoxic conditions in different gender ageing population groups
Progetto This project focuses on polyunsaturated fatty acids (PUFAs), specifically omega-3 fatty acids like EPA and DHA, in activating MCTR1 and its effects on muscle recovery and performance in high-intensity exercise. It explores the molecular mechanisms through which PUFAs influence MCTR1 signalling pathways, crucial in resolving inflammation and promoting tissue repair.
High-intensity exercise causes significant muscle damage and inflammation, leading to delayed recovery. Studies suggest that PUFAs possess anti-inflammatory properties and may enhance the resolution of inflammation through MCTR1 activation. However, the exact role of PUFA-activated MCTR1 in skeletal muscle tissues during and after intense exercise remains underexplored. This project aims to conduct in vitro experiments, animal studies, and human trials.
In vitro studies will focus on culturing skeletal muscle cells and macrophages, treating with different concentrations of PUFAs, and analyzing MCTR1 expression and related signalling pathways. Animal models, specifically high-intensity exercise-trained rodents, will be used to study the effects of PUFA-enriched diets on muscle inflammation, repair, and performance metrics. Finally, a randomized controlled trial with human participants will investigate the impact of PUFA supplementation on exercise performance and recovery, assessing both molecular biomarkers and functional performance outcomes.
The project’s findings provide new insights into the potential of PUFAs as a nutritional intervention for enhancing athletic performance and recovery. Additionally, the research will lead to the development of evidence-based dietary guidelines for athletes and active individuals, optimizing PUFA intake to support muscle health and performance. This work has significant implications for sports nutrition and may contribute to reducing the risk of exercise-related injuries and improving overall training outcomes.