00204 - MEDICINAL AND TOXICOLOGICAL CHEMISTRY 2

The course provides students with the tools for an analytical and critical approach to the discipline. Particular space is dedicated to understanding the phases of drug design and the molecular optimization approaches of the parent drugs. In the second part of the course, selected topics of pharmaceutical chemistry are proposed (antimicrobials, antiparasitics, anticancer drugs, hormones, cardiovascular drugs), the treatment of which insists on mechanistic, design and synthetic aspects. Students are provided with information on the chemical and chemical-physical properties of drugs, on their biological effects, on the molecular-based mechanism of action, on the relationships between structure and biological activity, on pharmacokinetic properties, on metabolic and toxicological pathways. The subject is characterized in its increasingly interdisciplinary connotations, with the aim of raising student awareness of the fascinating world of medicine.
Classroom learning: students are interactively stimulated to apply the knowledge they acquire through regular attendance to:
- understanding the relationships between chemical structure, properties, reactivity and biological activity of a drug
- prediction of the pharmacokinetic behavior and metabolic fate of bioactive molecules
- structural and mechanistic characterization of molecular targets
- formulation of drug modification strategies
- understanding of synthesis methodologies
- acquisition of correct terminology
Expected results: the student is expected to learn the fundamentals of the action of drugs and their complex interaction with different biological systems on a stereo-electronic basis. The methodological approach to which he has been directed will allow him to independently develop concepts and strategies, illustrated in class with specific examples, in any area of ​​the discipline. The student will be able to acquire the ability to develop the rational design and synthetic strategy of drugs for new macromolecules identified as targets. The preparation gained enables students to undertake a period of internship in a Pharmaceutical Chemistry laboratory.