00011 - DRUG ANALYSIS I (A-G)

courses
ID:
00011
Duration (hours):
112
CFU:
12
SSD:
CHIMICA FARMACEUTICA
Located in:
CHIETI
Url:
PHARMACY/CORSO GENERICO Year: 3
Year:
2026
Course Catalogue:
https://unich.coursecatalogue.cineca.it/af/2026?co...

Overview

Date/time interval

Primo Semestre (01/10/2026 - 31/01/2027)

Syllabus

Course Objectives


The aim of the course is to provide the theoretical and practical knowledge necessary for the quantitative determination of substances of pharmaceutical interest, using both chemical and instrumental methods, with particular regard to substances registered in the European Pharmacopoeia




Course Prerequisites


Preliminary examinations:

Organic Chemistry, Analytical Chemistry and analytical chemistry laboratory. Previous knowledge is represented by the contents of the General and Inorganic Chemistry Course on the following topics: stoichiometry, acid-base equilibria, electrochemistry, complexometry, of the Organic Chemistry Course relative to the properties of the main functional groups, and to the Course of Analytical Chemistry and Laboratory of Analytical Chemistry in relation to the titlings and the propaedeutic instrumental part




Teaching Methods


The course is divided into 72 hours of lectures and 48 hours of laboratory exercises




Assessment Methods


The exam consists of a written test (2 exercises for 80 min. Duration of the test) and an oral test. The candidate is admitted to the oral test with a minimum mark of 15/30. In the final evaluation, which will have as a starting point the voting of the written test, the Laboratory Exercises related to the unknown tests carried out during the course as well as the abilities of understanding and personal re-elaboration of the contents of the Italian and European Pharmacopoeia relative to monographs of the various active principles




Texts


- Analisi di preparazioni farmaceutiche, Porretta (CISU, Roma)

- Chimica Analitica Quantitativa, Harris (Zanichelli, Bologna)

- Chimica Analitica e Analisi Quantitativa, Hage - Carr (Piccin, Padova)




Contents


VOLUMETRIC ANALYSIS



General remarks

Introduction to quantitative pharmaceutical analysis. Classification of analytical methods. Quantitative and qualitative analysis. Sources of impurities in pharmaceutical products. General processes of quantitative pharmaceutical analysis. Drugs and purità codes. Italian and European Pharmacopeia.



Instrumentations, materials and reagents

Analytical and tecnica balance. Tasks connencted to sample weight. Errors in weight. Glassware. Reagents. Security in the lab.



Analytical methodologies base on titrations

General remarks. Volumetric titration. Types of reactions in volumetric titrations.érimary and secondary standards. Standard solutions. Concentration units. Titration curves. Equivalent weight. Calculations of volumetric analysis. Errors of volumetric analysis.



Acid-base titration in water

Water solutions and acid-base equilibria. Strength of acids and bases. pH. Acid-base indicators. Titration curves of strong acida and bases, and weak acids and bases. EU Pharmacopeia monographs



Titrations in non-aqueous solvents

General remarks. Classification of solvents. Strength of acids and bases in non-aqueous solvents. Autoprotolisis. Dielectric constants. EU Pharmacopeia monographs



Gravimetric titrations

General remarks. Solubility and Kps. Titration curves. Argentometry: Metodo di Mohr, Volhard and Fajans methods. EU Pharmacopeia monographs



Complexometric titrations

General remarks. Ligands. Chemlometry: titration with EDTA. Titration curves. Indicators. EU Pharmacopeia monographs



Redox titrations

General remarks. Nerst equation. Titration curves. Indicators.: Permanganomety, cerimetrya, titration with iodine- and bromine-bases species. EU Pharmacopeia monographs




Course Language


Italian

More information


https://fepifano.wixsite.com/sostanzenaturali

Degrees

Degrees

PHARMACY 
Single-cycle Master’s Degree
5 years
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