Innovation, digitalisation and sustainability for the diffused economy in Central Italy - VITALITY
Project The general purpose of the Ecosystem promoted by the 9 Universities of the three Regions of central Italy is the development and transfer of innovation to make regional production systems more competitive, thus improving sustainability, and to improve the quality of life in urban systems, rural areas, and both living and working environments. The three regions are characterized by an articulated production system both in terms of operational areas and in terms of size, with the presence of some large nationally renowned companies, but with the dominance presence being made up of small and medium-sized enterprises (SMEs). The main tools of the proposed innovation will be enabling technologies that are capable of acting transversally for the transformation of production and organizational systems and for production diversification. Such enabling technologies will include digital technologies for the acquisition and processing of data for the provision of services for development of sustainable production processes; technologies of nanomaterials and biocompatible materials, biotechnologies and health sciences, human sciences; and digital solutions for the implementation of production processes and the provision of services.
The activities (research, training, technology transfer and creation of start-ups/spin-offs and collaboration with SMEs) will be carried out by the 10 Spokes, with the participation of affiliate companies located in the regional territories and some research centres outside of the respective region
Overview
Contributor (39)
DI CARLO PIERO
Scientific Manager
ARUFFO ELEONORA
Participant
BALLERINI Patrizia
Participant
CAPALBO Antonio
Participant
CAPUTI Sergio
Participant
CATALDI Amelia
Participant
CAULO MASSIMO
Participant
CELIA Christian
Participant
CHIACCHIARETTA PIERO
Participant
CHIARELLI ANTONIO MARIA
Participant
CIPOLLONE Francesco
Participant
DELLA PENNA Stefania
Participant
DI BALDASSARRE Angela
Participant
DI MARZIO Luisa
Participant
DIOMEDE FRANCESCA
Participant
FERRETTI Antonio
Participant
FONTANA Antonella
Participant
FRANCIOTTI Raffaella
Participant
FULLE Stefania
Participant
GATTA Valentina
Participant
GHINASSI BARBARA
Participant
LOCATELLI Marcello
Participant
MERLA Arcangelo
Participant
MURMURA Giovanna
Participant
PERROTTI Vittoria
Participant
RE Nazzareno
Participant
RICCI FABRIZIO
Participant
RONCI Maurizio
Participant
SALLESE MICHELE
Participant
SANTILLI FRANCESCA
Participant
SENSI Stefano
Participant
SINJARI BRUNA
Participant
STEFANUCCI AZZURRA
Participant
TOMASSINI VALENTINA
Participant
TRAINI TONINO
Participant
TRUBIANI Oriana
Participant
VERGINELLI Fabio
Participant
VITACOLONNA Ester
Participant
WISE RICHARD GEOFFREY
Participant
Leading department (6)
DIPARTIMENTO DI FARMACIA
Aggregata
DIPARTIMENTO DI INGEGNERIA E GEOLOGIA
Aggregata
Term type
PNRR Ecosistemi dell'innovazione
Financier
M.U.R. - Ministero dell'Università e della Ricerca
Funding Organization
Partner (25)
Associazione della Croce Rossa Italiana
CONSIGLIO NAZIONALE DELLE RICERCHE
COSMOB S.p.A.
Dompé farmaceutici S.p.A.
Fondazione Bruno Kessler TRENTO
Gran Sasso Science Institute - Scuola Universitaria Superiore
INAF - Osservatorio Astronomico d'Abruzzo
INRCA - IRCCS Istituto nazionale di ricovero e cura per anziani
ISTITUTO PER IL RILEVAMENTO ELETTROMAGNETICO DELL'AMBIENTE DEL CONSIGLIO NAZIONALE DELLE RICERCHE (CNR-IREA)
ISTITUTO ZOOPROFILATTICO SPERIMENTALE DELL'ABRUZZO E DEL MOLISE "G. CAPORALE"
Meccano S.p.A.
Novamont S.p.A.
POLO TECNOLOGICO PIEMONTESE SRL
SYNERGO s.r.l.
THALES ALENIA SPACE ITALIA S.P.A.
THE GRAPHENE COMPANY S.R.L.
UNIVERSITA' DI MACERATA
UNIVERSITA' POLITECNICA DELLE MARCHE
Università degli Studi G.D'Annunzio di CHIETI
Università degli Studi de L'AQUILA
Università degli Studi del MOLISE - Dipartimento Bioscienze e Territorio
Università degli Studi di CAMERINO
Università degli Studi di PERUGIA
Università degli Studi di TERAMO
Università degli Studi di URBINO
Total Contribution (assigned) University (EUR)
13,364,077.2€
Date/time interval
July 1, 2022 - December 31, 2025
Project duration
42 months
Research
Concepts (5)
Free text keywords (7)
Health controlling systems and networks
Innovation
One-Health
Personalised medicine
Quality of life
Sustainability
telemedicine
No Results Found
Outputs
Outputs (61)
Induction of Cellular Senescence by Pesticide Exposure in Human Umbilical Vein Endothelial Cells (HUVECs): Impacts on Telomerase Length, Cellular Morphology, and mtDNA Variation
JOURNAL OF CELLULAR PHYSIOLOGY2026
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Activation of the NALP3-CASP1-IL-1 β Inflammatory Pathway by Pesticide Exposure in Human Umbilical Vein Endothelial Cells
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES2025
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2025
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Blood metabolome shows signatures of metabolic dysregulation in obese and overweight subjects that can be predicted by machine learning applied to heart rate variability
FRONTIERS IN MOLECULAR BIOSCIENCES2025
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Open Access
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Diagnosis and management of dilated cardiomyopathy: a systematic review of clinical practice guidelines and recommendations
EUROPEAN HEART JOURNAL. QUALITY OF CARE & CLINICAL OUTCOMES2025
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Open Access
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Endocrine-disrupting effects of environmental BPS and PFOS on human brain organoid development
FRONTIERS IN ENDOCRINOLOGY2025
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2025
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2025
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Hypertrophic cardiomyopathy management: a systematic review of the clinical practice guidelines and recommendations
EUROPEAN HEART JOURNAL. QUALITY OF CARE & CLINICAL OUTCOMES2025
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Interference of Estrogen Signaling by Endocrine Disruptors in Male and Female Cells: Potential Implications of BPS and PFOS in Human Development
EUROPEAN JOURNAL OF CELL BIOLOGY2025
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Machine learning models of Alzheimer's disease spectrum using blood tests
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING2025
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MiRNAs profile of extracellular vesicles from differentiated endothelial cells treated with chemical environmental pollutant BPA
SCIENTIFIC REPORTS2025
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Modafinil alters the functional connectivity of distinct thalamic nuclei with the neocortex
NEUROIMAGE2025
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2025
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New Insights into the oral microbiota and host epigenetic changes in obsessive compulsive disorder and major depressive disorder: Focus on BDNF
PHARMACOLOGICAL RESEARCH2025
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Phenolic terpenes in liposomal bilayers: Unraveling physicochemical interactions and membrane perturbation via biophysical and computational approaches
JOURNAL OF COLLOID AND INTERFACE SCIENCE2025
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Polystyrene microplastics are internalized by human gingival fibroblasts, enhance cell motility and induce molecular changes revealed through proteomic analysis
SCIENTIFIC REPORTS2025
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Rational construction of CQDs-based targeted multifunctional nanoplatform for synergistic chemo-photothermal tumor therapy.
JOURNAL OF COLLOID AND INTERFACE SCIENCE2025
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SOD-1/2 Involvement in the Antioxidant Molecular Events Occurring upon Complex Magnetic Fields Application in an In Vitro H2O2 Oxidative Stress-Induced Endothelial Cell Model
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES2025
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Stem Cells in Regenerative Medicine: A Journey from Adult Stem Cells to Induced Pluripotent Cells
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES2025
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The Immunophenotype and the Odontogenic Commitment of Dental Pulp Stem Cells Co-Cultured with Macrophages Under Inflammatory Conditions Is Modulated by Complex Magnetic Fields
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES2025
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2025
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2025
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Tuning the balance between CO2 absorption capacity and kinetics in diol-based low transition temperature mixtures: The dual role of 1,2-hexanediol
JOURNAL OF MOLECULAR LIQUIDS2025
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Urineprint of high-altitude: Insights from analyses of urinary biomarkers and bio-physical-chemical features of extracellular vesicles
BIOPHYSICAL CHEMISTRY2025
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Aggregation-induced emission of hybrid microcrystalline cellulose/metal-organic framework for selective spectrofluorometric detection of nirmatrelvir
MICROCHEMICAL JOURNAL2024
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Applications of metal organic frameworks in point of care testing
TRAC. TRENDS IN ANALYTICAL CHEMISTRY2024
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2024
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BOLD cardiorespiratory pulsatility in the brain: from noise to signal of interest
FRONTIERS IN HUMAN NEUROSCIENCE2024
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Open Access
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Biological Effects of PMMA and Composite Resins on Human Gingival Fibroblasts: An In Vitro Comparative Study
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES2024
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Biomimetic Platelet-Cloaked Nanoparticles for the Delivery of Anti-Inflammatory Curcumin in the Treatment of Atherosclerosis.
ADVANCED HEALTHCARE MATERIALS2024
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2024
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C-end rule peptide-guided niosomes for prostate cancer cell targeting.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY2024
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Data-driven analysis of whole-brain intrinsic connectivity in patients with chronic low back pain undergoing osteopathic manipulative treatment
NEUROIMAGE. CLINICAL2024
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Exploring Potential Impact of Graphene Oxide and Graphene Oxide-Polyethylenimine on Biological Behavior of Human Amniotic Fluid-Derived Stem Cells
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES2024
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Extracellular vesicles (EVs): A promising therapeutic tool in the heart tissue regeneration
BIOFACTORS2024
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2024
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Green extraction, chemical profile and biological activity of waste products from the olive oil industry: From Waste to Wealth
JOURNAL OF CHROMATOGRAPHY OPEN2024
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2024
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Innovative 3D-Printed Titanium Specimens Favor a Modulation of Inflammation in Dental Pulp Stem Cells During Liposome-Triggered Mineralization
THE INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS2024
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Moderate aortic stenosis: Navigating the uncharted
ECHOCARDIOGRAPHY2024
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Modulation of cerebellar-cortical connectivity induced by modafinil and its relationship with receptor and transporter expression
BIOLOGICAL PSYCHIATRY2024
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OX26-cojugated gangliosilated liposomes to improve the post-ischemic therapeutic effect of CDP-choline.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH2024
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Orthostatic hypotension is associated with higher levels of circulating endostatin
EUROPEAN HEART JOURNAL OPEN2024
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Unraveling the impact of different liposomal formulations on the plasma protein corona composition might give hints on the targeting capability of nanoparticles.
NANOSCALE ADVANCES2024
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3D Graphene Oxide-Polyethylenimine Scaffolds for Cardiac Tissue Engineering
ACS APPLIED MATERIALS & INTERFACES2023
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2023
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Anti-TLR4 biological response to titanium nitride-coated dental implants: anti-inflammatory response and extracellular matrix synthesis
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY2023
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2023
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Development of siRNA and Budesonide Dual-Loaded Hybrid Lipid-Polymer Nanoparticles by Microfluidics Technology as a Platform for Dual Drug Delivery to Macrophages: An In Vitro Mechanistic Study.
ADVANCED THERAPEUTICS2023
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Editorial: Collection on renal disease, diabetes and cognitive performance
FRONTIERS IN HUMAN NEUROSCIENCE2023
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2023
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Enriched Graphene Oxide-Polypropylene Suture Threads Buttons Modulate the Inflammatory Pathway Induced by Escherichia coli Lipopolysaccharide
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES2023
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Graphene oxide accelerates TGFβ-mediated epithelial-mesenchymal transition and stimulates pro-inflammatory immune response in amniotic epithelial cells
MATERIALS TODAY BIO2023
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Inhibition of LPS-Induced Inflammatory Response of Oral Mesenchymal Stem Cells in the Presence of Galectin-3
BIOMEDICINES2023
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Machine learning identifies phenotypic profile alterations of human dopaminergic neurons exposed to bisphenols and perfluoroalkyls
SCIENTIFIC REPORTS2023
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Metoprolol disrupts inflammatory response of human cardiomyocytes via β-arrestin2 biased agonism and NF-κB signaling modulation
BIOMEDICINE & PHARMACOTHERAPY2023
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Polyethylenimine-functionalized graphene quantum dots for Cd2+ ion adsorption.
NEW JOURNAL OF CHEMISTRY2023
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The Effects of Combined Exposure to Bisphenols and Perfluoroalkyls on Human Perinatal Stem Cells and the Potential Implications for Health Outcomes
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES2023
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Thermoresponsive M1 macrophage-derived hybrid nanovesicles for improved in vivo tumor targeting.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH2023
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Emerging Role of Oral Mesenchymal Stem/Stromal Cells and Their Derivates
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES2023
Review
Open Access
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