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  1. Projects

Innovation, digitalisation and sustainability for the diffused economy in Central Italy - VITALITY

Project
The general purpose of the Ecosystem promoted by the 9 Universities of the three Regions of central Italy is the development and transfer of innovation to make regional production systems more competitive, thus improving sustainability, and to improve the quality of life in urban systems, rural areas, and both living and working environments. The three regions are characterized by an articulated production system both in terms of operational areas and in terms of size, with the presence of some large nationally renowned companies, but with the dominance presence being made up of small and medium-sized enterprises (SMEs). The main tools of the proposed innovation will be enabling technologies that are capable of acting transversally for the transformation of production and organizational systems and for production diversification. Such enabling technologies will include digital technologies for the acquisition and processing of data for the provision of services for development of sustainable production processes; technologies of nanomaterials and biocompatible materials, biotechnologies and health sciences, human sciences; and digital solutions for the implementation of production processes and the provision of services. The activities (research, training, technology transfer and creation of start-ups/spin-offs and collaboration with SMEs) will be carried out by the 10 Spokes, with the participation of affiliate companies located in the regional territories and some research centres outside of the respective region
  • Overview
  • Research
  • Outputs

Overview

Contributor (39)

DI CARLO PIERO   Scientific Manager  
ARUFFO ELEONORA   Participant  
BALLERINI Patrizia   Participant  
CAPALBO Antonio   Participant  
CAPUTI Sergio   Participant  
CATALDI Amelia   Participant  
CAULO MASSIMO   Participant  
CELIA Christian   Participant  
CHIACCHIARETTA PIERO   Participant  
CHIARELLI ANTONIO MARIA   Participant  
CIPOLLONE Francesco   Participant  
DELLA PENNA Stefania   Participant  
DI BALDASSARRE Angela   Participant  
DI MARZIO Luisa   Participant  
DIOMEDE FRANCESCA   Participant  
FERRETTI Antonio   Participant  
FONTANA Antonella   Participant  
FRANCIOTTI Raffaella   Participant  
FULLE Stefania   Participant  
GATTA Valentina   Participant  
GHINASSI BARBARA   Participant  
LOCATELLI Marcello   Participant  
MERLA Arcangelo   Participant  
MURMURA Giovanna   Participant  
PERROTTI Vittoria   Participant  
RE Nazzareno   Participant  
RICCI FABRIZIO   Participant  
RONCI Maurizio   Participant  
SALLESE MICHELE   Participant  
SANTILLI FRANCESCA   Participant  
SENSI Stefano   Participant  
SINJARI BRUNA   Participant  
STEFANUCCI AZZURRA   Participant  
TOMASSINI VALENTINA   Participant  
TRAINI TONINO   Participant  
TRUBIANI Oriana   Participant  
VERGINELLI Fabio   Participant  
VITACOLONNA Ester   Participant  
WISE RICHARD GEOFFREY   Participant  

Leading department (6)

DIPARTIMENTO DI FARMACIA   Aggregata  
DIPARTIMENTO DI INGEGNERIA E GEOLOGIA   Aggregata  
DIPARTIMENTO DI MEDICINA E SCIENZE DELL'INVECCHIAMENTO   Aggregata  
DIPARTIMENTO DI NEUROSCIENZE, IMAGING E SCIENZE CLINICHE   Aggregata  
DIPARTIMENTO DI SCIENZE MEDICHE, ORALI E BIOTECNOLOGICHE   Aggregata  
DIPARTIMENTO DI TECNOLOGIE INNOVATIVE IN MEDICINA & ODONTOIATRIA   Aggregata  

Term type

PNRR Ecosistemi dell'innovazione

Financier

M.U.R. - Ministero dell'Università e della Ricerca
Funding Organization

Partner (25)

Associazione della Croce Rossa Italiana
CONSIGLIO NAZIONALE DELLE RICERCHE
COSMOB S.p.A.
Dompé farmaceutici S.p.A.
Fondazione Bruno Kessler TRENTO
Gran Sasso Science Institute - Scuola Universitaria Superiore
INAF - Osservatorio Astronomico d'Abruzzo
INRCA - IRCCS Istituto nazionale di ricovero e cura per anziani
ISTITUTO PER IL RILEVAMENTO ELETTROMAGNETICO DELL'AMBIENTE DEL CONSIGLIO NAZIONALE DELLE RICERCHE (CNR-IREA)
ISTITUTO ZOOPROFILATTICO SPERIMENTALE DELL'ABRUZZO E DEL MOLISE "G. CAPORALE"
Meccano S.p.A.
Novamont S.p.A.
POLO TECNOLOGICO PIEMONTESE SRL
SYNERGO s.r.l.
THALES ALENIA SPACE ITALIA S.P.A.
THE GRAPHENE COMPANY S.R.L.
UNIVERSITA' DI MACERATA
UNIVERSITA' POLITECNICA DELLE MARCHE
Università degli Studi G.D'Annunzio di CHIETI
Università degli Studi de L'AQUILA
Università degli Studi del MOLISE - Dipartimento Bioscienze e Territorio
Università degli Studi di CAMERINO
Università degli Studi di PERUGIA
Università degli Studi di TERAMO
Università degli Studi di URBINO

Total Contribution (assigned) University (EUR)

13,364,077.2€

Date/time interval

July 1, 2022 - December 31, 2025

Project duration

42 months

Research

Concepts (5)


Goal 11: Sustainable cities and communities

Goal 13: Climate action

Goal 3: Good health and well-being

Goal 9: Industry, Innovation, and Infrastructure

Settore FIS/06 - Fisica per il Sistema Terra e Il Mezzo Circumterrestre

Free text keywords (7)

  • ascendant
  • decrescent
Health controlling systems and networks
Innovation
One-Health
Personalised medicine
Quality of life
Sustainability
telemedicine
No Results Found
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Outputs

Outputs (61)

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  • Academic Article
  • Review
Induction of Cellular Senescence by Pesticide Exposure in Human Umbilical Vein Endothelial Cells (HUVECs): Impacts on Telomerase Length, Cellular Morphology, and mtDNA Variation 
JOURNAL OF CELLULAR PHYSIOLOGY
2026
Academic Article
none Access
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Activation of the NALP3-CASP1-IL-1 β Inflammatory Pathway by Pesticide Exposure in Human Umbilical Vein Endothelial Cells 
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2025
Academic Article
Open Access
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Angiogenic Events Positively Modulated by Complex Magnetic Fields in an In Vitro Endothelial Cell Model 
CELLS
2025
Academic Article
Open Access
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Blood metabolome shows signatures of metabolic dysregulation in obese and overweight subjects that can be predicted by machine learning applied to heart rate variability 
FRONTIERS IN MOLECULAR BIOSCIENCES
2025
Academic Article
Open Access
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Diagnosis and management of dilated cardiomyopathy: a systematic review of clinical practice guidelines and recommendations 
EUROPEAN HEART JOURNAL. QUALITY OF CARE & CLINICAL OUTCOMES
2025
Academic Article
Open Access
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Endocrine-disrupting effects of environmental BPS and PFOS on human brain organoid development 
FRONTIERS IN ENDOCRINOLOGY
2025
Academic Article
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Epigenetic alterations and microbiota changes in the saliva of individuals with binge-eating spectrum disorders compared with normal weight healthy controls 
LIFE SCIENCES
2025
Academic Article
none Access
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Evaluation of Antibody-Drug Conjugate Performances Using a Novel HPLC-DAD Method for Tumor-Specific Detection of DM4 and S-Methyl-DM4 
ACS OMEGA
2025
Academic Article
Open Access
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Hypertrophic cardiomyopathy management: a systematic review of the clinical practice guidelines and recommendations 
EUROPEAN HEART JOURNAL. QUALITY OF CARE & CLINICAL OUTCOMES
2025
Academic Article
Open Access
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Interference of Estrogen Signaling by Endocrine Disruptors in Male and Female Cells: Potential Implications of BPS and PFOS in Human Development 
EUROPEAN JOURNAL OF CELL BIOLOGY
2025
Academic Article
Open Access
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Machine learning models of Alzheimer's disease spectrum using blood tests 
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
2025
Academic Article
none Access
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MiRNAs profile of extracellular vesicles from differentiated endothelial cells treated with chemical environmental pollutant BPA 
SCIENTIFIC REPORTS
2025
Academic Article
none Access
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Modafinil alters the functional connectivity of distinct thalamic nuclei with the neocortex 
NEUROIMAGE
2025
Academic Article
Open Access
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Nature's Synergy: Cellular and Molecular Evaluation of Snail Slime and Its Principal Component, Glycolic Acid, on Keratinocytes, with Preliminary Evidence from Endothelial Cells 
BIOMOLECULES
2025
Academic Article
Reserved Access
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New Insights into the oral microbiota and host epigenetic changes in obsessive compulsive disorder and major depressive disorder: Focus on BDNF 
PHARMACOLOGICAL RESEARCH
2025
Academic Article
none Access
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Phenolic terpenes in liposomal bilayers: Unraveling physicochemical interactions and membrane perturbation via biophysical and computational approaches 
JOURNAL OF COLLOID AND INTERFACE SCIENCE
2025
Academic Article
Open Access
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Polystyrene microplastics are internalized by human gingival fibroblasts, enhance cell motility and induce molecular changes revealed through proteomic analysis 
SCIENTIFIC REPORTS
2025
Academic Article
none Access
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Rational construction of CQDs-based targeted multifunctional nanoplatform for synergistic chemo-photothermal tumor therapy. 
JOURNAL OF COLLOID AND INTERFACE SCIENCE
2025
Academic Article
none Access
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SOD-1/2 Involvement in the Antioxidant Molecular Events Occurring upon Complex Magnetic Fields Application in an In Vitro H2O2 Oxidative Stress-Induced Endothelial Cell Model 
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2025
Academic Article
Open Access
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Stem Cells in Regenerative Medicine: A Journey from Adult Stem Cells to Induced Pluripotent Cells 
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2025
Academic Article
none Access
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The Immunophenotype and the Odontogenic Commitment of Dental Pulp Stem Cells Co-Cultured with Macrophages Under Inflammatory Conditions Is Modulated by Complex Magnetic Fields 
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2025
Academic Article
Open Access
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Three-Dimensional Culture System: A New Frontier in Cancer Research, Drug Discovery, and Stem Cell-Based Therapy 
BIOLOGY
2025
Academic Article
Open Access
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Transcriptomic Profile of Early Antral Follicles: Predictive Somatic Gene Markers of Oocyte Maturation Outcome 
CELLS
2025
Academic Article
none Access
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Tuning the balance between CO2 absorption capacity and kinetics in diol-based low transition temperature mixtures: The dual role of 1,2-hexanediol 
JOURNAL OF MOLECULAR LIQUIDS
2025
Academic Article
none Access
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Urineprint of high-altitude: Insights from analyses of urinary biomarkers and bio-physical-chemical features of extracellular vesicles 
BIOPHYSICAL CHEMISTRY
2025
Academic Article
Open Access
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Aggregation-induced emission of hybrid microcrystalline cellulose/metal-organic framework for selective spectrofluorometric detection of nirmatrelvir 
MICROCHEMICAL JOURNAL
2024
Academic Article
none Access
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Applications of metal organic frameworks in point of care testing 
TRAC. TRENDS IN ANALYTICAL CHEMISTRY
2024
Academic Article
Open Access
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Assessment of the in-vitro toxicity and in-vivo therapeutic capabilities of Juglans regia on human prostate cancer and prostatic hyperplasia in rats 
FOOD BIOSCIENCE
2024
Academic Article
Open Access
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BOLD cardiorespiratory pulsatility in the brain: from noise to signal of interest 
FRONTIERS IN HUMAN NEUROSCIENCE
2024
Academic Article
Open Access
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Biological Effects of PMMA and Composite Resins on Human Gingival Fibroblasts: An In Vitro Comparative Study 
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2024
Academic Article
Open Access
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Biomimetic Platelet-Cloaked Nanoparticles for the Delivery of Anti-Inflammatory Curcumin in the Treatment of Atherosclerosis. 
ADVANCED HEALTHCARE MATERIALS
2024
Academic Article
Open Access
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Blood Pressure Regulation in Post–COVID POTS: Beyond Sinus Tachycardia 
HYPERTENSION
2024
Academic Article
Open Access
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C-end rule peptide-guided niosomes for prostate cancer cell targeting. 
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
2024
Academic Article
Open Access
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Data-driven analysis of whole-brain intrinsic connectivity in patients with chronic low back pain undergoing osteopathic manipulative treatment 
NEUROIMAGE. CLINICAL
2024
Academic Article
Open Access
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Exploring Potential Impact of Graphene Oxide and Graphene Oxide-Polyethylenimine on Biological Behavior of Human Amniotic Fluid-Derived Stem Cells 
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2024
Academic Article
Open Access
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Extracellular vesicles (EVs): A promising therapeutic tool in the heart tissue regeneration 
BIOFACTORS
2024
Academic Article
Open Access
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Garlic Peel-based Carbon Quantum Dots as a Sustainable Alternative for the Sensitive and Green Spectrofluorometric Quantification of Molnupiravir in Pharmaceutical Capsules 
HELIYON
2024
Academic Article
none Access
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Green extraction, chemical profile and biological activity of waste products from the olive oil industry: From Waste to Wealth 
JOURNAL OF CHROMATOGRAPHY OPEN
2024
Academic Article
Open Access
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Impact of Composition and Autoclave Sterilization on the Mechanical and Biological Properties of ECM-Mimicking Cryogels 
POLYMERS
2024
Academic Article
Open Access
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Innovative 3D-Printed Titanium Specimens Favor a Modulation of Inflammation in Dental Pulp Stem Cells During Liposome-Triggered Mineralization 
THE INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS
2024
Academic Article
Embargoed Access
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Moderate aortic stenosis: Navigating the uncharted 
ECHOCARDIOGRAPHY
2024
Academic Article
none Access
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Modulation of cerebellar-cortical connectivity induced by modafinil and its relationship with receptor and transporter expression 
BIOLOGICAL PSYCHIATRY
2024
Academic Article
Open Access
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OX26-cojugated gangliosilated liposomes to improve the post-ischemic therapeutic effect of CDP-choline. 
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
2024
Academic Article
Open Access
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Orthostatic hypotension is associated with higher levels of circulating endostatin 
EUROPEAN HEART JOURNAL OPEN
2024
Academic Article
Open Access
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Unraveling the impact of different liposomal formulations on the plasma protein corona composition might give hints on the targeting capability of nanoparticles. 
NANOSCALE ADVANCES
2024
Academic Article
Open Access
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3D Graphene Oxide-Polyethylenimine Scaffolds for Cardiac Tissue Engineering 
ACS APPLIED MATERIALS & INTERFACES
2023
Academic Article
Open Access
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A549 as an In Vitro Model to Evaluate the Impact of Microplastics in the Air 
BIOLOGY
2023
Academic Article
Open Access
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Anti-TLR4 biological response to titanium nitride-coated dental implants: anti-inflammatory response and extracellular matrix synthesis 
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
2023
Academic Article
Open Access
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Comparison of Machine Learning-based Approaches to Predict the Conversion to Alzheimer's Disease from Mild Cognitive Impairment 
NEUROSCIENCE
2023
Academic Article
Reserved Access
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Development of siRNA and Budesonide Dual-Loaded Hybrid Lipid-Polymer Nanoparticles by Microfluidics Technology as a Platform for Dual Drug Delivery to Macrophages: An In Vitro Mechanistic Study. 
ADVANCED THERAPEUTICS
2023
Academic Article
none Access
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Editorial: Collection on renal disease, diabetes and cognitive performance 
FRONTIERS IN HUMAN NEUROSCIENCE
2023
Academic Article
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Enhanced CO2 Capture by Sorption on Electrospun Poly (Methyl Methacrylate) 
SEPARATIONS
2023
Academic Article
Open Access
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Enriched Graphene Oxide-Polypropylene Suture Threads Buttons Modulate the Inflammatory Pathway Induced by Escherichia coli Lipopolysaccharide 
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2023
Academic Article
Open Access
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Graphene oxide accelerates TGFβ-mediated epithelial-mesenchymal transition and stimulates pro-inflammatory immune response in amniotic epithelial cells 
MATERIALS TODAY BIO
2023
Academic Article
Open Access
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Inhibition of LPS-Induced Inflammatory Response of Oral Mesenchymal Stem Cells in the Presence of Galectin-3 
BIOMEDICINES
2023
Academic Article
Open Access
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Machine learning identifies phenotypic profile alterations of human dopaminergic neurons exposed to bisphenols and perfluoroalkyls 
SCIENTIFIC REPORTS
2023
Academic Article
Open Access
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Metoprolol disrupts inflammatory response of human cardiomyocytes via β-arrestin2 biased agonism and NF-κB signaling modulation 
BIOMEDICINE & PHARMACOTHERAPY
2023
Academic Article
Open Access
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Polyethylenimine-functionalized graphene quantum dots for Cd2+ ion adsorption. 
NEW JOURNAL OF CHEMISTRY
2023
Academic Article
none Access
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The Effects of Combined Exposure to Bisphenols and Perfluoroalkyls on Human Perinatal Stem Cells and the Potential Implications for Health Outcomes 
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2023
Academic Article
Open Access
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Thermoresponsive M1 macrophage-derived hybrid nanovesicles for improved in vivo tumor targeting. 
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
2023
Academic Article
Open Access
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Emerging Role of Oral Mesenchymal Stem/Stromal Cells and Their Derivates 
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2023
Review
Open Access
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